1-based numbering is the computational idea of indexing an ordered data structure (e.g., a
string or array) by starting with 1 instead of 0. For example, if $s$ is the string
"ACGT", then $s$ is given by the symbol 'A' and $s$ is 'C'.
By default, problems in Rosalind's Bioinformatics Stronghold will use 1-based numbering instead of 0-based numbering,
which is used by Python.